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Henry Pownall
Baylor College of MedicineDepartment: MedicineAddress: Alkek Tower, A654 Houston, TX 77030 Phone: 713-798-4160 Fax: 713-798-5134 Email: hpownall@bcm.edu Web: http://www.bcm.edu/medicine/athero/?PMID=5154 |
Education
Elizabethtown College (1965), B.S. Chemistry
Wilkes College (1967), M.S. Chemistry
Northeastern University (1970), Ph.D. Chemistry
Postdoc, University of Houston and Baylor College of Medicine
Honors
Josephine S. Abercrombie Chair of Atherosclerosis & Lipoprotein Research
American Institute of Chemists Award
Established Investigator of The American Heart Association
Alumni Award in Chemistry, Elizabethtown College
Elizabethtown College Educate-for-Service Professional Achievement Award
Editorial Board Member–Journal of Protein Chemistry, Journal of Biological Chemistry
Research Topic
Structures of Native and Model Plasma Lipoproteins
Research Description
Research in the Pownall laboratory uses structural and mechanistic approaches to developing new methods for the reversal of heart disease. Major concepts include thermodynamics and chemical kinetics. The major methodology is fluorescence spectroscopy. Studies extend from purely biochemical/biophysical to cell and mouse studies of cardioprotection via novel mechanisms. Ancillary methods include immunoblotting, fluorescence microscopy, calorimetry, mass spectrometry.
Selected Publications
- Pownall HJ, Hosken BD, Gillard BK, Higgins CL, Lin HY, and Massey JB. Speciation of Human Plasma High Density Lipoprotein: HDL Stability and Apolipoprotein A-I Partitioning. 2007 Biochemistry 46:7449-59
- Gillard BK, Courtney HS, Massey JB, and Pownall HJ. Serum Opacity Factor Unmasks Human Plasma High Density Lipoprotein Instability via Selective Delipidation and Apolipoprotein A-I Desorption. 2007 Biochemistry 2007 46:12968-12978.
- Massey JB, and Pownall HJ, Cholesterol Determines the Structures of Discoidal High Density Lipoproteins Formed by the Microsolubilization of Phospholipid Membranes by Apolipoprotein A-I. Biochim Biophys Acta, 2008 1781:245-53.
- Pownall HJ, Courtney HS, Gillard BK and MasseyJB. Properties of the Products Formed by the Activity of Serum Opacity Factor against Human Plasma High Density Lipoproteins. Chem Phys Lipids 2008 156:45-51.
- Han M, Gillard BK, Courtney HS, Ward K, Rosales C, Khant H, Ludtke SJ, and Pownall HJ. Disruption of Human Plasma High Density Lipoproteins by Streptococcal Serum Opacity Factor Requires Labile Apolipoprotein A-I. Biochemistry, 2009 48:1481-7
- Massey JB, Pownall HJ, Macha S, Morris J, Tubb MR and Gangani D. Silva RA. Mass Spectrometric Determination of Apolipoprotein Molecular Stoichiometry in Reconstituted High Density Lipoprotein Particles. J Lipid Res. 50:1229-36.
- Ruan H and Pownall HJ. Adipocyte IKK/NF-κB: A Therapeutic Target for Insulin Resistance. Curr Opin Investig Drugs. 2009 10:346-52.
- Gillard BK, Lin H-Y, Massey JB, Pownall HJ, Apolipoproteins A-I, A-II and E are independently distributed among intracellular and newly secreted HDL of human hepatoma cells. Biochim Biophys Acta - Molecular and Cell Biology of Lipids 2009 In press.
- Rosales C, Gillard BK, Courtney HS, Blanco-Vaca F, and Pownall HJ. Apolipoprotein Modulatino of Streptococcal Serum Opacity Factor Activity against Human Plasma High Density Lipoproteins. Biochemistry, in press.
- Huang S, Henry L, Ho YK, Pownall HJ, and Gabby Rudenko. Mechanism of LDL Binding and Release Probed by Structure-based Mutagenesis of the LDL Receptor. 2009 J Lipid Res. In press.
Lab Members
Current Graduate Students
Current Post Docs
Lab Photos
Last edited on: September 10, 2009