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Florante A. Quiocho
Baylor College of MedicineDepartment: Biochemistry & Molecular BiologyAddress: One Baylor Plaza, Room T517 Houston, TX 77030 Phone: 713-798-6565 Fax: 713-798-8516 Email: faq@bcm.tmc.edu Web: www.bcm.edu/biochem/?PMID=3780 |
Education
B.S. Chemistry, Central Philippine Univ.
Ph.D. Molecular Biophysics and Biochemistry, Yale (1966)
Department of Chemistry, Harvard University
Honors
Research Topic
Protein Atomic Structure, Molecular Recognition and Function
Research Description
Three-dimensional structures of biological macromolecules lie at the very core of understanding, at the atomic level, biological and biochemical processes. Our research interest is centered on the study of the tertiary structure and function of proteins and enzymes at atomic resolution. Although X-ray crystallography is the primary experimental approach to achieve this goal, other correlative studies employing biochemical, physical-chemical and recombinant DNA techniques are also being pursued. The many proteins under investigation cover the areas of signal transduction and cellular regulation, ligand and drug molecular recognition, active transport, enzyme mechanism, immunology of bacterial cell surface protein and oligosaccharide antigens, DNA/RNA binding, and endocytosis.
Selected Publications
- Chen, J., Lu, G., Lin, J., Davidson, A.L. and Quiocho, F.A. (2003). A tweezer-like motion of the ATP-binding cassette dimer in an ABC transport cycle. Mol. Cell 12: 651-661.
- Moure, C.M., Gimble, F.S. and Quiocho, F.A.(2002). Crystal structure of the intein homing endonuclease PI-SceI bound to its recognition sequence. Nat. Struct. Biol. 9: 764-770.
- Duan, X. and Quiocho, F.A. (2002). Structural Evidence for the Dominant Role of Nonpolar Interactions in the Binding of a Transport/Chemosensory Receptor to its Highly Polar Ligands. (Accelerated publication). Biochemistry 41: 706-712.
- Chen, J., Sharma, S., Quiocho, F.A., and Davidson, A.L. (2001). Trapping the Transition State of an ABC Transporter:Evidence for a Concerted Mechanism of Maltose Transport. Proc. Natl. Acad. Sci. USA 98: 1525-1530.
- Mao, Y., Chen, J.,Maynard, J.A., Zhang, B., and Quiocho, F.A. (2001). A Novel All helix Fold of the AP180 Amino Terminal Domain for Phosphoinositide Binding and Clathrin Assembly in Synaptic Vesicle Endocytosis. Cell 104: 433-440.
- Mao, Y., Nickitenko, A., Duan, X., Llyod, T.E., Wu, M., Bellen, H., and Quiocho, F.A. (2000). Crystal Structure of the VHS and FYVE Tandem Domains of Hrs, a Protein Involved in Membrane Trafficking and Signal Transduction. Cell 100: 447-456.
- Quiocho, F.A., Hu, G. and Gershon, P.D. (2000). Structural Basis for mRNA Cap Recognition by Proteins. Curr. Opin. Struct. Biol. 10: 78-86.
Lab Members
Lab Photos
Last edited on: September 22, 2009