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James Carson, Ph.D. Baylor College Medicine Department: Post Doctorate, Pacific Northwest National Laboratory Address: Richland, Washington Phone: Fax: Email: james.carson@gmail.com Web:

Education

B.S. Electrical Engineering, Rice University (1996)
M.E.E. Electrical Engineering, Rice University (1996)
Ph.D., Structural and Computational Biology and Molecular Biophysics (2004)
Postdoc, Biochemistry & Molecular Biology, Baylor College of Medicine (2004-05)

Honors

Keck Center for Computational Biology Undergraduate Research Fellowship
Rice Engineering Alumni Herbert Allen Outstanding Junior Award
Electrical and Computer Engineering Senior Project Award

Research Topic

Characterization and comparison of gene expression patterns in mouse brain

Research Description

The focus of this research is to develop and utilize technologies to perform analysis on gene expression data throughout the mouse brain at cellular resolution. This begins with data collection using high-throughput in situ hybridization, followed by image processing for expression signal detection. The expression patterns are placed into an atlas of the mouse brain, a common coordinate system built using subdivision mesh technology. The results are organized in an online database (www.geneatlas.org) that enables queries and comparisons. Finally, cluster analysis techniques are used for data mining.

Selected Publications

• Carson JP, Eichele G, Chiu W. (2005). A method for automated detection of gene expression required for the establishment of a digital transcriptome-wide gene expression atlas. J. Microsc. 217: 275-281.
• Tao Ju, Joe Warren, Gregor Eichele, Christina Thaller, Wah Chiu, James Carson (2003). A Geometric Database for Gene Expression Data. Eurographics Symposium on Geometry Processing.
• Zangwill KM, Greenberg DP, Chiu CY, Mendelman P, Wong VK, Chang SJ, Partridge S, Ward JI. (2003). Safety and immunogenicity of a heptavalent pneumococcal conjugate vaccine in infants. Vaccine. 21(17-18): 1894-1900.
• James Carson, Christina Thaller, Gregor Eichele (2002). A Transcriptome Atlas of the Mouse Brain at Cellular Resolution. Curr. Opin. Neurobiol. 12(5): 562-565.

Last edited on: December 12, 2005