Ph.D. Program in Structural and
Computational Biology and
Molecular Biophysics

Left. A surface representation (green) of an acrosomal filament isolated from the acrosomal bundle. The major features include a central column of density to which we can fit the atomic model of actin (subunits shown in red, white, and blue). Helically wound around this is the cross-linker, scruin, which binds strongly to the actin of this filament and makes other interactions with the scruin of neighboring filaments to form the crystalline bundle.
Left. A surface representation (green) of an acrosomal filament isolated from the acrosomal bundle. The major features include a central column of density to which we can fit the atomic model of actin (subunits shown in red, white, and blue). Helically wound around this is the cross-linker, scruin, which binds strongly to the actin of this filament and makes other interactions with the scruin of neighboring filaments to form the crystalline bundle.
Right. A surface representation of botulinum toxin molecules bound to a phospholipid vesicle tube. The smooth inner surface of the vesicle is perforated by channels formed when the toxin undergoes a conformational change at the pH of the lysosomal vesicle. Most of the protein remains outside the 800-Å diameter vesicle and forms protein-protein interactions that create the pore.
Right. A surface representation of botulinum toxin molecules bound to a phospholipid vesicle tube. The smooth inner surface of the vesicle is perforated by channels formed when the toxin undergoes a conformational change at the pH of the lysosomal vesicle. Most of the protein remains outside the 800-Å diameter vesicle and forms protein-protein interactions that create the pore.
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