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Patrick Barth
Baylor College of MedicineDepartment: Pharmacology, Biochemistry & Molecular BiologyAddress: One Baylor Plaza Houston, Texas 77030 Phone: 713-798-8508 Fax: 713-798-3145 Email: patrickb@bcm.edu Web: |
Education
B.S. Physics and Chemistry (University of Paris VI - France) (1994)
Master, Bioinorganic Chemistry (University of Paris XI Orsay - France (1996)
Ph.D., Biophysics (University of Paris XI Orsay / CEA Saclay - France) (2000)
UC Berkeley; University of Washington
Honors
HONORS
2000: PhD title with highest honors
1996: Master of Bioinorganic Chemistry with highest honors
1995: Bachelor honor degree with highest honors
1994: Bachelor degree with highest honors
FELLOWSHIPS AND AWARDS
1999- 2000: CNRS doctoral research fellowship
1997- 1999: CEA doctoral research fellowship
1995- 1996: Ministry of Education fellowship
Research Topic
Signaling mechanisms across biological membranes by computational modeling, design and experimental biophysics
Research Description
My lab is interested in how signals are faithfully transmitted across biological membranes. How do receptors sense and respond to diverse ligands? How do receptors communicate with each other in the membrane? How do receptor-receptor interactions modulate signaling? Can we recapitulate these properties by design and rewire signaling pathways?
We address these questions using a combination of molecular modeling, bioinformatics and experimental approaches to model, design and reprogram receptor/ligand interaction networks. Our long-term goal is to deconstruct the complex function and quantitatively describe the basic principles underlying these signaling networks.
We have developed an ensemble of physical models and computational methods to model and design receptor structures and interactions. We have also combined experimental data with modeling techniques to model specific functional states of receptors. Finally, we have cross-validated our predictions experimentally. This interdisciplinary approach is essential to our research and we welcome students and postdocs with computational and experimental backgrounds to continue fostering a very collaborative environment in the lab.
Selected Publications
- Michino, M., et al. Community-wide assessment of GPCR structure modelling and ligand docking : GPCR Dock 2008 (2009) Nature Review Drug Discovery 8(6), 455-63.
- Barth, P.*, Zhu, J.*, Luo, B.H.*, Schonbrun, J., Baker, D., Springer, T. The structure of a receptor with two associating transmembrane domains on the cell surface : integrin αIIbβ3. (2009) Molecular Cell 34(2), 234-49.
- Barth, P.*, Wallner, B.*, Baker, D. Prediction of membrane protein structures with complex topologies using limited constraints. (2009) Proc Natl Acad Sci U S A (Track II) 106(5), 1409-14.
- Barth, P., Schoeffler, A., Alber, T. Targeting metatstable coiled-coil domains by computational design (2008) Journal of the American Chemical Society, 130(36), 12038-44.
- Barth, P. Modulating membrane protein stability and association by design (2007) Current Opinon in Structural Biology 17(4), 460-466.
- Pathak, M.*, Yarov-Yarovoy, V.*, Agarwal, G., Roux, B., Barth, P., Kohout, S., Tombola, F., Isacoff , E.U. Closing in on the resting state of the shaker K+ channel (2007) Neuron 56(1), 124-140.
- Barth, P., Schonbrun, J., Baker D. Toward high-resolution prediction and design of transmembrane helical protein structures (2007) Proc Natl Acad Sci U S A (Track II) 104(40), 15682-15687.
- Barth, P., Alber, T., Harbury, P.B. Accurate, conformation-dependent predictions of solvent effects on protein ionization constants (2007) Proc Natl Acad Sci U S A (Track I) 104(12), 4898-903.
- Versele, M.L.A., Gullbrand, B., Shulewitz, M.J., Cid, V.J., Bahmanyar, S., Chen, R.E., Barth, P., Alber, T., Thorner J. Protein-protein interactions governing septin heteropentamer assembly and septin filament organization in Saccharomyces cerevisiae (2004) Mol Biol Cell 15, 4568-83.
- Barth, P., Savarin, P., Gilquin, B., Lagoutte, B., Ochsenbein, F. Solution NMR structure and backbone dynamics of the PsaE subunit of the photosystem I from Synechocystis sp. PCC 6803 (2002) Biochemistry 41, 13902-14.
- Barth, P.*, Guillouard, I.*, Setif, P., Lagoutte, B. Essential role of a single arginine of photosystem I in stabilizing the electron transfer complex with ferredoxin (2000) Journal of Biological Chemistry 275(10), 7030-6.
- Barth, P., Lagoutte, B., Setif, P. Ferredoxin Reduction by Photosystem I from Synechocystis sp. PCC 6803 : Towards an understanding of the respective roles of subunits PsaD and PsaE in ferredoxin binding (1998) Biochemistry 37, 16233-16241.
Lab Members
Lab Photos
Last edited on: November 06, 2009