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Ido Golding Baylor College of Medicine Department: Biochemistry and Molecular Biology Address: One Baylor Plaza, BCM 125 Houston, TX 77030 Phone: 713-798-4193 Fax: 713-796-9438 Email: golding@bcm.edu Web: www.bcm.edu/biochem/?PMID=11830

Education

Technion ‐ Israel Institute of Technology Physics B.Sc., 1991
Tel Aviv University, Israel Physics M.Sc., 1997
Tel Aviv University, Israel Physics Ph.D., 2001
Princeton University, USA Molecular Biology Post‐doctoral, 2001‐2006

Honors

2000 The Dothan Foundation Award for Academic Achievement, Tel Aviv University, Israel
2001 Lewis Thomas Fellowship, Princeton University, USA
2008 Human Frontier Science Program, Young Investigators Award

Research Topic

Spatio-temporal dynamics in living cells

Research Description

In my lab, we examine the way living cells process information from their environment and make decisions based on that information. Our aim is to form a quantitative narrative for the dynamics of cellular decision-making and unveil simple principles that underlie such processes. As a model system, we use the bacterium E. coli and its virus, phage lambda. We study their complex interaction at the level of individual events in space and time.

Work in the lab involves a set of skills broader than what is generally mastered within a single discipline, including the techniques of microbiology and molecular genetics; live single-cell microscopy for making dynamic measurements; and data analysis using the engineer's toolbox of signal- and image processing; all accompanied by the theoretical tools of dynamical systems theory, stochastic processes, non-equilibrium phenomena and more. The practice of modern in vivo biology, combined with the intellectual effort of a quantitative approach, will contribute significantly to a young scientist's training experience, better preparing them for the future world of "Systems Biology".

Selected Publications

• I. Golding “A study of a two‐dimensional lattice model of polymers with short‐range interactions” M.Sc. Thesis, Tel‐Aviv University (1996).
• I. Golding and Y. Kantor “Two‐dimensional polymers with random short‐range interactions” Phys. Rev. E 56 (2) R1318‐R1321 (1997).
• I. Golding, Y. Kozlovsky, I. Cohen and E. Ben‐Jacob “Studies of bacterial branching growth using reaction‐diffusion models of colonial development” Physica A 260 (3‐4) 510‐554 (1998).
• Y. Kozlovsky, I. Cohen, I. Golding and E. Ben‐Jacob “Lubricating bacteria model for branching growth of bacterial colonies” Phys. Rev. E. 59 (6) 7025‐7035 (1999).
• I. Cohen, I. Golding, Y. Kozlovsky and E. Ben‐Jacob “Continuous and discrete models of cooperation in complex bacterial colonies” Fractals 7 (3) 235‐247 (1999).
• I. Golding, I. Cohen and E. Ben‐Jacob “Studies of sector formation in expanding bacterial colonies” Europhys. Lett. 48 (5) 587‐593 (1999).
• I. Golding, I. Cohen and E. Ben‐Jacob “Studies of bacterial cooperative organization” in Traffic and Granular Flow ʹ99: SOCIAL, TRAFFIC, AND GRANULAR DYNAMICS (D. Helbing, H. J. Herrmann, M. Schreckenberg and D. E. Wolf, Eds.), Springer‐Verlag, Berlin (2000).
• I. Cohen, I. Golding, I.G. Ron and E. Ben‐Jacob “Biofluiddynamics of lubricating bacteria” Math. Meth. Appl. Sci. 24 (17‐18) 1429‐1468 (2001).
• I. Golding, I. Cohen, I.G. Ron and E. Ben‐Jacob “Adaptive branching during colonial development of lubricating bacteria” in Branching in Nature (V. Fleury, J.F. Gouyet and M. Leonetti, Eds.), EDP Sciences, Les Ulis (2001).
• E. Ben‐Jacob, I. Cohen and I. Golding “Modeling branching and chiral colonial patterning of lubricating bacteria” in Mathematical Models for Biological Pattern Formation (H. Othmer and P. Maini, Eds.), Springer‐Verlag, Berlin (2000).
• E. Ben‐Jacob, I. Cohen, I. Golding, D.L. Gutnick, M. Tcherpakov, D. Helbing and I.G. Ron “Bacterial cooperative organization under antibiotic stress” Physica A 282 (1‐2) 247‐282 (2000).
• I. Golding and E. Ben‐Jacob “The artistry of bacterial colonies and the antibiotic crisis” in Coherent Structures in Complex Systems (D. Reguera, L.L. Bonilla, and J.M. Rubí, Eds.), Springer‐Verlag, Heidelberg (2001).
• I. Golding, B. Drossel, Y. Shapira and E. Ben‐Jacob “A Quantitative Study of the Dynamics of Adaptive Mutation Appearance” Physica A 294 (1‐2) 195‐212 (2001).
• I. Golding “Studies of Bacterial Cooperative Organization Using Continuous Models” Ph.D. Thesis, Tel‐Aviv University (2001).
• O. Shefi, I. Golding, R. Segev, E. Ben‐Jacob and A. Ayali “Morphological characterization of in‐vitro neuronal networks” Phys. Rev. E. 66 (2) 021905 (2002).
• I.G. Ron, I. Golding, B. Lifsitz‐Mercer and E. Ben‐Jacob “Bursts of sectors in expanding bacterial colonies as a possible model for tumor growth and metastases” Physica A 320 485‐496 (2003).
• U. Nevo, J. Kipnis, I. Golding, I. Shaked, A. Neumann, S. Akselrod and M. Schwartz “Autoimmunity as a special case of immunity: removing threats from within” Trends in Molecular Medicine 9 (3) 88‐93 (2003).
• U. Nevo, I. Golding, A. U. Neumann, M. Schwartz and S. Akselrod “Autoimmunity as an immune defense against degenerative processes: a primary mathematical model illustrating the bright side of autoimmunity” Journal of Theoretical biology 227 (4) 583‐592 (2004).
• I. Golding and E. C. Cox “RNA dynamics in live E. coli cells” Proc. Natl. Acad. Sci. USA 101 (31) 11310‐11315 (2004).
• Y. Chen, I. Golding, S. Sawai, L. Guo and E. C. Cox “Population fitness and the regulation of Escherichia coli genes by bacterial viruses” PLoS Biol. 3(7): e229 (2005).
• Y. M. Wang, J. O. Tegenfeldt, W. Reisner, R. Riehn, X.‐J. Guan, L. Guo, I. Golding, E. C. Cox, J. Sturm and R. H. Austin “Single‐molecule studies of repressor‐DNA interactions show long‐range interactions” Proc. Natl. Acad. Sci. USA 102 (28) 9796‐9801 (2005).
• I. Golding, J. Paulsson, S. M. Zawilski and E. C. Cox “Real‐time kinetics of gene activity in individual bacteria” Cell 123 (6) 1025‐1036 (2005).
• I. Golding and E. C. Cox “Physical nature of bacterial cytoplasm” Phys. Rev. Lett. 96, 098102 (2006).
• I. Golding and E. C. Cox “Eukaryotic transcription: What does it mean for a gene to be ‘on’?” Curr. Biol. 16 (10) R371‐R373 (2006).
• I. Golding and E. C. Cox “Protein synthesis molecule by molecule” Genome Biol. 7:212 (2006).
• I. Golding and E. C. Cox, “Spatiotemporal Dynamics in Bacterial Cells: Real‐Time Studies with Single‐Event Resolution”, In: H. W. Detrich, and J. J. Correia (Editors), METHODS IN CELL BIOLOGY, Vol. 89, BIOPHYSICAL TOOLS FOR BIOLOGISTS, VOL 2: IN VIVO TECHNIQUES, Academic Press (2008).
• Y. Wang, L. Guo, I. Golding, E. C. Cox and N. P. Ong “Quantitative transcription factor binding kinetics at the single‐molecule level” Biophys. J. 96 (2) 609‐620 (2009).
• N. Chia, I. Golding and N. Goldenfeld “Lambda‐prophage induction modeled as a cooperative failure mode of lytic repression” Phys. Rev. E, accepted for publication
• T. L. Min, P. J. Mears, L. M. Chubiz, C. V. Rao, I. Golding and Y. R. Chemla, “High‐resolution, long‐term characterization of bacterial motility using optical tweezers” Nature Methods, accepted for publication.
• C. Zong, L. So and I. Golding “Stability of cell state depends on the number of activity bursts from the fate‐determining gene” Submitted for publication.

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Last edited on: January 26, 2010