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Rudy Guerra
Rice UniversityDepartment: StatisticsAddress: 2100 Duncan Hall Statistics Department Rice University Houston, TX 77005 Phone: (713) 348-5453 Fax: (713) 348-5476 Email: rguerra@rice.edu Web: www.stat.rice.edu/~rguerra/ |
Education
B.S., Applied Mathematics, UT San Antonio
M.A., Mathematics, UC Berkeley
Ph.D., Statistics, UC Berkeley
Honors
Sigma Xi for Outstanding Scientific Research (1999)
National Research Council Postdoctoral Award (1991)
Graduate Student Outstanding Teaching Award (UC Berkeley, 1988)
National Hispanic Scholarship Fellow (1985‑86, 1989)
National Institutes of Health MARC Fellow (1985‑89)
Research Topic
Meta-analysis for genetic linkage studies, case-control studies using haplotype blocks, and identification of multiple genetic markers influencing a single trait.
Research Description
1. National Institutes of Health (NCI, 2003-2008). A training program in biostatistics for cancer research. Investigator and Co-Director [Gary Rosner (MDACC), PI]
2. National Institutes of Health (2002-2006). Modeling lung cancer: Risks, progression, and screening. Co-investigator. (Marek Kimmel, PI, Rice University)
3. National Science Foundation (2002-2005). Bioinformatics: From sequence to expression and structure – An innovative research-oriented course. Co-Principal Investigator. (Marek Kimmel, PI, Rice University)
4. National Institutes of Health (2002-2009). Proteomics Technologies to Study Airway Inflammation. Co-investigator. (A. Kurosky, PI, UTMB-Galveston)
I am generally interested in biological problems with an emphasis in biomedical research. Longtime collaboration with investigators from University of Texas Southwestern Medical Center have centered on statistical genetics whereby statistical methods are developed to analyze genetic data, especially with a view toward genotype-phenotype relationships. Such efforts include study design for genetic epidemiologic studies, linkage and association, and statistical models to account for both genetic and environmental factors influencing heritable traits. Current interests include meta-analysis for genetic linkage studies, case-control studies using haplotype blocks, and identification of multiple genetic markers influencing a single trait. More recently, I have been learning about bioinformatics via microarray studies and biological pathways. Projects in these areas are motivated by various system biology efforts with University of Texas Medical Branch (UTMB,Galveston), Baylor College of Medicine, and MD Anderson Cancer Center.
Selected Publications
- Guerra, R. (2002). Meta-analysis in human genetics studies. In Biostatistcal Genetics and Genetic Epidemiology, R. Elston, J. Olson, & L. Palmer (eds), Wiley Reference in Biostatistics.
- Berge, K., von Bergmann, K., Lutjohann, D., Guerra, R., Grundy, S., Hobbs, H., and Cohen, J. (2002). Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8, Journal of Lipid Research, 43:486-494.
- Etzel, C. and Guerra, R. (2002) Meta-analysis of genetic linkage analysis of quantitative trait loci. American Journal of Human Genetics, 71:56-65.
- Shohet, R.V., Vega, G.L., Bersot, T.P., Mahley, R.W., Grundy, S.M., Guerra, R., Cohen, J.C. (2002). Sources of variability in genetic association studies: Insights from the analysis of hepatic lipase (LIPC), Human Mutation, 19:536-542.
- Han, J. and Guerra, R. (2003) Cost efficiency of genetic linkage studies using mixtures of selected sib-pairs. Science and Statistics: Festschtrift for Terence Speed, D. Goldstein (ed.). Institute of Mathematical Statistics, Lecture Notes-Monograph Series, Volume 40.
- Valentine, J., Guerra, R. and Cohen, J. (2003). Family History is a Major Determinant of Subclinical Peripheral Arterial Disease in Young Adults, Journal of Vascular Surgery, in press.
- Valentine RJ, Guerra R, Stephan P, Scoggins E, Clagett GP, Cohen J (2004). Family history is a major determinant of subclinical peripheral arterial disease in young adults. Journal of Vascular surgery 39 (2): 351-356
- Jain T, Peshock R, McGuire DK, Willett D, Yu ZX, Vega GL, Guerra R, Hobbs HH, Grundy SM (2004). African Americans and Caucasians have a similar prevalence of coronary calcium in the Dallas heart study. Journal of the American College of Cardiology 44 (5): 1011-1017
- Guerra R, Yu ZX, Marcovina S, Peshock R, Cohen JC, Hobbs HH (2005). Lipoprotein(a) and apolipoprotein(a) isoforms - No association with coronary artery calcification in the Dallas Heart Study . Circulation 111 (12): 1471-1479
Lab Members
Lab Photos
Last edited on: September 21, 2009