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Mary E. Dickinson, Ph.D.
Baylor College of MedicineDepartment: Dept. of Molecular Physiology & BiophysicsAddress: One Baylor Plaza, Rm. T421 Houston, TX 77030 Phone: (713) 798-2104 Fax: (713) 798-3475 Email: mdickins@bcm.edu Web: www.bcm.edu/physio/faculty/dickinson/dickinson.htm |
Education
Ph.D., Columbia University
Postdoctoral, Caltech
Honors
Research Topic
In vivo optical microscopy; Analysis of vascular networks; Role of mechanical forces in vertebrate development
Research Description
My laboratory uses a multi-disciplinary approach to study the role of fluid-derived mechanical forces in vascular remodeling and heart morphogenesis in early vertebrate embryos. We have recently developed methods for time-lapse, confocal imaging of rapid blood flow and heart mechanics using vital fluorescent protein reporters. With these methods we are studying the response to changes in mechanical stress in mouse and zebrafish models, taking advantage of the wealth of mutant animals.
Selected Publications
- Jones, E.A.V., Crotty, D., Kulesa, P.M., Waters, C.W., Baron, M.H., Fraser, S.E., and Dickinson, M.E.(2002). Dynamic In Vivo Imaging of Post Implantation Mammalian Embryos Using Whole Embryo Culture. Genesis 34: 228-35.
- Dickinson, M.E., Simbuerger, E., Zimmermann, B., Waters, C.W. and Fraser, S.E. (2003). Multiphoton Spectra in Biological Samples. J. Biomed. Optics 8: 329-338.
- Hadjantonakis, A.-K., Dickinson, M.E, Fraser, S.E., and Papaioannou, V.E. (2003). Technicolour Transgenics: Imaging tools for functional genomics in the mouse. Nature Rev. Genet. 4: 613-625.
- Jones, E.A.V., Baron, M.H., Fraser, S.E. and Dickinson, M.E. (2004). Hemodynamic Changes During the Development of the Mammalian Vasculature. Am. J. Physiol. Heart Circ. Physiol. 287: 1561-1569.
- Fraser, S.T., Hadjantonakis, A-K., Sahr, K.E., Willey, S., Kelly, O.G., Jones, E.A.V., Dickinson, M.E. and Baron, M.H. (2005). Using a Histone Yellow Fluorescent Protein Fusion For Tracking Endothelial Cells in ES cells and Mice. Genesis 42: 162-171.
- Liebling, M., Farouhar, A.S., Gharib, M., Fraser, S.E. and Dickinson, M.E. 4-Dimensional Cardiac Imaging of Living Embryos via Post-Acquisition Synchronization of Nongated Slice-Sequences. J. Biomed. Optics, in press.
- Fraser ST, Hadjantonakis AK, Sahr KE, Willey S, Kelly OG, Jones EA, Dickinson ME, Baron MH (2005) Using a histone yellow fluorescent protein fusion for tagging and tracking endothelial cells in ES cells and mice. Genesis 42:162-171.
- Wang J, Hamblet NS, Mark S, Dickinson ME, Brinkman BC, Segil N, Fraser SE, Chen P, Wallingford JB, Wynshaw-Boris A (2006) Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development 133:1767-1778.
- Forouhar AS, Liebling M, Hickerson A, Nasiraei-Moghaddam A, Tsai HJ, Hove JR, Fraser SE, Dickinson ME, Gharib M (2006) The embryonic vertebrate heart tube is a dynamic suction pump. Science 312:751-753.
- Lucitti JL, Dickinson ME (2006) Moving toward the light: using new technology to answer old questions. Pediatric Research 60:1-5.
- Liebling M, Forouhar AS, Wolleschensky R, Zimmermann B, Ankerhold R, Fraser SE, Gharib M, Dickinson ME (2006) Rapid three-dimensional imaging and analysis of the beating embryonic heart reveals functional changes during development. Developmental Dynamics 235:2940-2948.
Lab Members
Lab Photos
Last edited on: November 21, 2005