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Lei Chen
Baylor College of MedicineDepartment: SCBMBAddress: Baylor College of Medicine One Baylor Plaza Houston, TX 77030 Currently as remote student at Washington University Genome Sequecing Center 4444 Forest Park Ave St. Louis, MO 63110 Phone: Fax: Email: lc1@bcm.edu Web: genome.wustl.edu |
Education
B.S. in Biology, Fudan University, China (2005)
Mentor: George Weinstock
Honors
Marc Dresden Excellence in Graduate Education Award (2006)
Research Topic
Computational Genomics
Research Description
I have been working on genomic sequence assembly and related analysis. I assembled the low coverage dolphin genome and wallaby genome; analyzed the polymorphisms in several microbial genome as well as Dr. Watson's genome. Currently I am working on the meta-genomics aspect of the Human Microbiome Project. In detail, the project will study the symbiotic microbes within certain human organ as a whole, especially the ensemble of their genomes. We will be dealing with DNA sequence fragments from multiple microbes at differing abundunce together, possibly produced by different sequencing technologies. We do not only want to assemble them into longer more contiguous sequence, we want to set the standard to measure the diversity and other ensemble characteristics of the data, and develop methods to compare different individuals' metagenomics data directly. It could turn out that one's microbiome is equally important as one's genome in terms of disease diagnosis.
Selected Publications
- DA Wheeler et al. The complete genome of an individual by massively parallel DNA sequencing. Nature. 2008 Apr 17;452(7189):872-6.
Last edited on: April 27, 2008