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Steve Ludtke
Baylor College of MedicineDepartment: BiochemistryAddress: 1 Baylor Plaza Houston, TX 77030 Phone: 713-798-9020 Fax: 713-798-1625 Email: sludtke@bcm.edu Web: ncmi.bcm.tmc.edu |
Education
B.S. Physics, Caltech(1990)
M.A. Physics, Rice University(1993)
Ph.D. Physics, Rice University(1996)
Honors
Burton Medal, 2008
Research Topic
electron cryomicroscopy, scientific image processing, structural biology, supercomputing
Research Description
My work focuses on electron cryomicroscopy and scientific image processing. While much of my group's focus is on computational work, as codirector of the National Center for Macromolecular Imaging, I also have access to all of the NCMI facilities, and my lab does experimental work as well. My interests cover a wide range of techniques in this field, including: single particle reconstruction, tomography and 2D crystallography. Single particle reconstruction is my primary focus, and my major contribution to the field is the development of EMAN, a software suite for processing images of individual molecules and producing 3D structures at subnanometer resolution. This is extremely computationally intensive work, and we have several in-house Linux clusters used in processing and development. My interests include all aspects of scientific image processing, development of ontology-based scientific databases, Grid (and other massively parallel) computational techniques, scientific visualization and animation. I'm involved in a wide range of biological projects including chaperonins, protein-lipid interactions, ribozymes, ion channels, and many others.
Selected Publications
- Tang, G., Peng, L., Baldwin, P. R., Mann, D. S., Jiang, W., Rees, I., and Ludtke, S. J. (2007). EMAN2: An extensible image processing suite for electron microscopy. J Struct Biol. 157:38-46.
- Ludtke, S.J., Chen, D.H., Song, J.L., Chuang, D.T., and Chiu, W. (2004). Seeing GroEL at 6 A resolution by single particle electron cryomicroscopy. Structure (Camb) 12: 1129-1136.
- Ludtke, S.J., Serysheva, I.I., Hamilton, S.L. and Chiu, W. (2005) The pore structure of the closed RyR1 channel. Structure. 8:1203-11.
- Chen, D.H., Song, J.L., Chuang, D.T., Chiu, W., Ludtke, S.J. (2006). An expanded conformation of single-ring GroEL-GroES complex encapsulates an 86 kDa substrate. Structure. 11:1711-1722.
- Ludtke, S.J., Nason, L., Tu, H., Peng, L., and Chiu, W. (2003). Object oriented database and electronic notebook for transmission electron microscopy. Microsc. Microanal. 9: 556-565.
- Ludtke, S.J., and Chiu, W. (2003). Focal pair merging for contrast enhancement of single particles. J. Struct. Biol. 144: 73-78.
- Arac, D., Chen, X., Khant, H.A., Ubach, J., Ludtke, S.J., Kikkawa, M., Johnson, A.E., Chiu, W., Sudhof, T.C., Rizo, J. (2006) Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol. 13(3):209-17.
- S.J. Ludtke, K. He, W. T. Heller, T. A. Harroun, L. Yang and H.W. Huang. (1996). Membrane pores induced by magainin. Biochemistry. 35, 13723-13728.
Lab Members
Current Graduate Students
Current Post Docs
Lab Photos
Last edited on: August 21, 2009