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Jian Wang
Baylor College of MedicineDepartment: SCBMBAddress: 6621 Fannin St. MS 3-3320 Houston, TX 77030 Phone: (832) 824-4864 Fax: (832) 825-4038 Email: jxwang@txccc.org Web: |
Education
B.S. Microbiology, Wuhan University, China
M.S. Computer Science, The University of Georgia
Mentor: Ching C. Lau, M.D., Ph.D.
Honors
Best Oral Presentation, BCM SCBMB Research Conference 2009
John R. Kelsey, Jr. Student Speaker Award, BCM Graduate Student Symposium 2008
Professor John J. Trentin Scholarship Award (Highest GPA in 1st year of Graduate School) 2005
Research Topic
To identify tumor subtypes and improve outcome prediction for medulloblastoma, the most common malignant brain tumor in children, by comprehensive genomic profiling.
Research Description
My dissertation research involves studying medulloblastoma, the most common malignant brain tumor in children. The major goals are two-fold. First, I will apply the SNP (single nucleotide polymorphism) arrays to examine the clinical samples of medulloblastoma, along with matched controls. Combined with the expression array analysis of medulloblastoma, the SNP arrays will help to identify prognostic markers as a collaborating effort with the Children's Oncology Group for the diagnosis and treatment of medulloblastoma. Second, based on the microarray analysis, I will pinpoint genes that are possibly involved in the genetic and biochemical signaling pathways of medulloblastoma tumorigenesis. Subsequently, functional studies of those genes will be carried out both in vitro and in vivo.
Selected Publications
- Hall D, Bhandarkar SM, Wang J. (2001) ODS2: a multiplatform software application for creating integrated physical and genetic maps. Genetics. 157(3):1045-56.
- Kraemer E, Wang J, Guo J, Hopkins S, Arnold J. (2001) An analysis of gene-finding programs for Neurospora crassa. Bioinformatics. 17(10):901-12.
- Wang J, Kraemer E. (2003) GFPE: gene-finding program evaluation. Bioinformatics. 19(13):1712-3.
- Jian Wang, Tsz-Kwong Man, Kwong Kwok Wong, Pulivarthi H. Rao, Hon-Chiu Eastwood Leung, Rudy Guerra, Ching C. Lau. Genome-Wide Analysis of Copy Number Variations in Normal Population Identified by SNP Arrays. (2009) The Open Biology Journal. Volume 2:54-65.
- David C. Marciano, Jeanine M. Pennington, Xiaohu Wang, Jian Wang et al. Genetic and Structural Characterization of an L201P Global Suppressor Substitution in TEM-1 ß-Lactamase. Journal of Molecular Biology. 2008. 384(1): 151-64.
- Ching C. Lau and Jian Wang. Genomic Profiling and Personalized Medicine. Enterprise Imaging and Therapeutic Radiology Management. 2008. 18(3): 32
- Jian Wang and Eileen Kraemer. GFPE: gene-finding program evaluation. Bioinformatics. 2003. 19(13): 1712-13.
- Eileen Kraemer, Jian Wang, Jinhua Guo et al. An analysis of gene-finding programs for Neurospora crassa. Bioinformatics. 2001. 7(10): 901-12.
- David Hall, Suchendra M. Bhandarkar, and Jian Wang. ODS2: A Multiplatform Software Application for Creating Integrated Physical and Genetic Maps. Genetics. 2001. 157(3): 1045-56.
Last edited on: September 02, 2009