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Christopher Booth
Baylor College of MedicineDepartment: ConsultantAddress: Phone: Fax: Email: christopher.booth@gmail.com Web: |
Education
B.Sc. Biochemistry and Microbiology, University of Victoria (2000)
Ph.D., Structural and Computational Biology and Molecular Biophysics (2006)
Honors
2003: Best Poster Award CMB/SCBMB Retreat
2003-2004: Robert A. Welch Predoctoral Fellowship
Research Topic
“Developing and Applying Tools for Data Collection in Electron Cryomicroscopy”
Research Description
We are developing technology to help facilitate electron cryomicroscopy at subnanometer resolution called JAMES (JEOL Automated Microscopy Expert System). We have formed a close partnership with JEOL to produce a commercial quality software for electron cryomicroscopy.
We have begun to use this software to answer specific questions about several biological systems. These systems include a prototypical reovirus, Cytoplasmic Polyhedrosis Virus and a eukaryotic group II Chaperonin, TCP-1 Ring Complex.
Selected Publications
- Jiang W, Li Z, Zhang Z, Booth CR, Baker ML, Chiu W. (2001) Semi-automated icosahedral particle reconstruction at sub-nanometer resolution. J Struct Biol. 136(3):214-25
- Flynn TC, Swint-Kruse L, Kong Y, Booth C, Matthews KS, Ma J. (2003) Allosteric transition pathways in the lactose repressor protein core domains: asymmetric motions in a homodimer. Protein Sci. 12(11):2523-41.
- Booth CR, Jiang W, Baker ML, Zhou ZH, Ludtke SJ, Chiu W. (2004) A 9 Å Single Particle Reconstruction from CCD Captured Images on a 200 kV Electron Cryomicroscope. J Struct Biol. 147:116-127
- Passmore LA, Booth CR, Venien-Bryan C, Ludtke SJ, Fioretto C, Johnson LN, Chiu W, Barford D. (2005) Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation. Mol. Cell. 20(6):855-66
- Yu X, Acehan D, Menetret JF, Booth CR, Ludtke SJ, Riedl SJ, Shi Y, Wang X, Akey CW. (2005) A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform. Structure. 13(11):1725-35
Last edited on: April 26, 2006