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Guanghui Hu, Ph.D.Department: Principal Scientist, GlaxoSmithKline Address: 709 Swedeland Rd. Mail code: UW2230 King of Prussia, PA 19406 Phone: 610-270-6926 Fax: Email: guanghui.2.hu@gsk.com Web: |
Education
B.S., Bioscience & Biotechnology, Tsinghua University (1992)
M.S., Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences (1995)
Ph.D., Structural and Computational Biology and Molecular Biophysics (2000)
Postdoctoral Fellow, Dept. of Chemistry & Biochemistry, UCLA
Honors
Research Topic
Thesis:
Research Description
Research Description: Systems Biology in Drug Discovery
Postdoctoral Fellow, Dept. of Chemistry & Biochemistry, UCLA (2000 - 01)
Research Scientist, Tanox, Inc. (2001-03)
Principal Scientist, GlaxoSmith Kline (2003 - present)
Selected Publications
- Hu G, Jain K, Hurle M (2005). Revealing transforming growth factor – beta signaling transduction in human kidney by gene expression data mining (Submitted).
- Wang SW, Oh CK, Cho SH, Hu G, Martin R, Demissie-Sanders S, Li K, Moyle M, Yao Z. (2005). Amphiregulin expression in human mast cells and its effect on the primary human lung fibroblasts. J. Allergy Clin. Immunol. 115(2): 287-294.
- Hu G, Tsai AL, Quiocho FA. (2003). Insertion of an N7-methylguanine mRNA cap between two coplanar aromatic residues of a cap-binding protein is fast and selective for a positively charged cap. J. Biol. Chem. 278(51): 51515-51520.
- Yang J, Hu G, Wang SW, Li Y, Martin R, Li K, Yao Z. (2003). Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway. J. Biol. Chem. 278(19): 16797-16801.
- Hu G, Modrek B, Stensland H, Saarela J, Pajukanta P, Kustanovich V, Peltonen L, Nelson S, Lee C (2002). Efficient identification of single-nucleotide polymorphisms in coding regions of human genes. Pharmacogenomics J. 2: 236.
- Hu G, Oguro A, Li C, Gershon PD, Quiocho FA. (2002). The "cap-binding slot" of an mRNA cap-binding protein: quantitative effects of aromatic side chain choice in the double-stacking sandwich with cap. Biochemistry. 41(24): 7677-7687.
- Irizarry K, Hu G, Wong ML, Licinio J, Lee C (2001). Single nucleotide polymorphism identification in candidate gene systems of obesity. Pharmacogenomics J 1: 193.
- Quiocho FA, Hu G, Gershon PD. (2000). Structural basis of mRNA cap recognition by proteins. Curr. Opin. Struct. Biol. 10: 78.
- Hu G, Gershon PD, Hodel A, Quiocho FA. (1999). mRNA cap recognition: dominant role of enhanced stacking interactions between methylated bases and protein aromatic sidechains. Proc. Natl. Acad. Sci. U.S.A. 96: 7149.
Last edited on: April 26, 2006