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Cecilia Clementi
Rice UniversityDepartment: Dept. of ChemistryAddress: Rice University 6100 Main street Houston, Texas, 77005-1892 Phone: (713) 348-3485 Fax: (713) 348-5155 Email: cecilia@rice.edu Web: leonardo.rice.edu/~cecilia/research/ |
Education
B.S. Physics, University of Florence, Firenze, Italy (1995)
M.S. Physics, Int.l School for Advanced Studies, Trieste, Italy (1996)
Ph.D. Physics, Int.l School for Advanced Studies, Trieste, Italy (1998)
Postdoctoral Fellow, Department of Physics and Department of Chemistry and Biochemistry, UCSD, 1998-2001
Honors
NSF-CAREER award, 2004–2009
Norman Hackerman Welch Young Investigator award, 2001–2004
La Jolla Interfaces in Science (LJIS) fellowship (supported by the Burroughs Wellcome Fund), 1999–2001.
SISSA research scholarship, 1995-1998
Research Topic
Theory of Protein Folding; Protein Modeling and Simulations; Folding/Function relationship
Research Description
Dr. Clementi's research activity lays at interface of Physics, Chemistry and Biology. Her current research interests concern the theoretical and computational investigation of protein folding, protein interactions and functions. Her most recent research has been focused on the definition and exploration of protein models with different levels of complexity aimed to study, and possibly predict, the folding mechanism of real proteins. The models and theories developed so far have been successfully applied to a set of monomeric proteins. In the very near future, the study will be enlarged to include protein-protein interactions and assembling, in order to proceed toward an understanding of biological functions. Such studies can have important applications in pharmacology and medicine.
For more information, see the website at http://leonardo.rice.edu/~cecilia
Selected Publications
- Clementi, C., Garcia, A.E. and Onuchic, J.N. (2003). Interplay among tertiary contacts, secondary structure formation and side-chain packing in the protein folding mechanism: all-atom representation study of protein L. J. Mol. Biol. 326: 933-54.
- Clementi, C., Jennings, P.A. and Onuchic, J.N. (2001). Prediction of folding mechanism for circular-permuted proteins. J. Mol. Biol. 311: 879-890.
- Clementi, C., Jennings, P.A. and Onuchic, J.N. (2000). How native state topology affects the folding of Dihydrofolate Reductase and Interleukin-1b. Proc. Natl. Acad. Sci. USA 97: 5871-5876.
- Clementi, C., Nymeyer. H. and Onuchic, J.N. (2000). Topological and energetic factors: what determines the structural details of the transition state ensemble and on-route intermediates for protein folding? An investigation for small globular proteins. J. Mol. Biol. 298: 937-953.
- C. Clementi, M. Vendruscolo, A. Maritan, E. Domany (1999). Folding Lennard-Jones proteins by a contact potential. Proteins 97: 544-553.
- C. Clementi, P. Carloni, A. Maritan (1999). Protein design is a key factor for subunit-subunit association. Proc. Natl. Acad. Sci. USA 96: 9616-9621.
- C. Clementi, A. Maritan, J.R. Banavar (1998). Folding, design, and determination of interaction potentials using off-lattice dynamics of model heteropolymers. Phys. Rev. Letters 81: 3287-3290.
- J.van Mourik, C. Clementi, A. Maritan, F. Seno, J.R. Banavar (1999). Determination of interaction potentials of amino acids from native protein structures: Tests on simple lattice models. J. Chem. Phys. 110: 10123-10133.
Lab Members
Lab Photos
Last edited on: September 21, 2009