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Srinivasan Madabushi, Ph.D.
Baylor College of MedicineDepartment: Associate Consultant, ZS AssociatesAddress: San Francisco, CA Phone: Fax: Email: smadabushi@gmail.com Web: imgen.bcm.tmc.edu/molgen/labs/lichtarge/ |
Education
B.Sc (Hons) Human Biology (1999), All India Institute of Medical Sciences, New Delhi, India
Ph.D., Structural and Computational Biology and Molecular Biophysics (2005)
Honors
Rockwell Scholar -1999
Best Poster Award - Keck/Gulf Coast Consortium 2002 Bioinformatics Symposium
Selected to talk in Graduate Student Symposium 2002
Best SCBMB Talk - 2003 CMB and SCBMB Research Conference
Best SCBMB Talk - 2004 CMB and SCBMB Research Conference
Research Topic
Thesis: “Evolutionary Analysis of G-Protein Coupled Receptors’ Structure and Function”
Research Description
Identifying & distinguishing specificities in ligand binding and receptor dimerization in G-Protein Coupled Receptors using an evolutionary approach.
Selected Publications
- Rajagopalan L, Patel N, Madabushi S, Goddard JA, Anjan V, Lin F, Shope C, Farrell B, Lichtarge O, Davidson AL, Brownell WE, Pereira FA. Essential Helix Interactions in the Anion Transporter Domain of Prestin Revealed by Evolutionary Trace Analysis. J Neurosci. 2006 Dec 6;26(49):12727-12734.
- Madabushi S, Gross AK, Philippi A, Meng EC, Wensel TG, Lichtarge O. Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions. J. Biol. Chem. 2004; 279(9): 8126-32
- Lichtarge O, Yao H, Kristensen DM, Madabushi S, Mihalek I. Accurate and scalable identification of functional sites by evolutionary tracing. J. Struct. Functional Genomics. 2003; 4 (2-3): 159-166.
- Lin CY, Varma MG, Joubel A, Madabushi S, Lichtarge O, Barber DL. Conserved motifs in somatostatin, D2-dopamine, and Alpha2B-adrenergic receptors for inhibiting the Na-H exchanger NHE1. J. Biol. Chem. 2003 Apr 25;278(17):15128-35
- Madabushi S, Yao H, Marsh M, Kristensen DM, Philippi A, Sowa ME, Lichtarge O. Structural clusters of evolutionary trace residues are statistically significant and common in proteins.J Mol Biol. 2002 Feb 8;316(1):139-54.
- Shakti, S., Srinivasan, M. and Kothekar,V. 530ps Molecular dynamics simulation of NSAIDs with COX-1 and COX-2. Study of perturbative changes. J. Mol. Struct. 498:133-138 (1999).
- Kothekar V, Sahi S, Srinivasan M. Computer simulation of the interaction of non-steroidal anti-inflammatory drugs: indoprofen and NS398 with cyclooxygenase. J Biomol Struct Dyn 1999 Feb;16(4):901-15
- Kothekar V, Sahi S, Srinivasan M, Mohan A, Mishra J. Recognition of cyclooxygenase-2 (COX-2) active site by NSAIDs: a computer modelling study. Indian J Biochem Biophys 2001 Feb-Apr;38(1-2):56-63
Last edited on: March 28, 2007