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Mathew Sowa Baylor College of Medicine Department: Postdoctural Fellow in the lab of Dr. Wade Harper, Harvard Medical School Address: Harvard Medical School Department of Pathology 77 Avenue Louis Pasteur NRB 940 Boston, MA 02115 Phone: Fax: Email: mathew_sowa@hms.harvard.edu Web: 134.174.17.106/pathol/labs/harper/NearFinalsite/harperwebpageNF.htm

Education

B.A. Biology, Tufts University, Medford, MA (1995); B.S. Physics, Univeristy of Massachusetts, Amherst, MA (1997)
Ph.D., Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine (2002)

Honors

W.M. Keck Center for Computational Biology Predoctoral fellow (1998-2001)
Best oral presentation CMB/SCBMB retreat, 1999, 2001

Research Topic

Computational and Experimental Investigations into G protein signaling pathways.

Research Description

Selected Publications

• Imanishi Y, Li N, Sokal I, Sowa ME, Lichtarge O, Wensel TG, Saperstein DA,Baehr W, Palczewski K. Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man.Eur J Neurosci. 2002 Jan;15(1):63-78.
• Lichtarge O, Sowa ME. Evolutionary predictions of binding surfaces and interactions. Curr Opin Struct Biol. 2002 Feb;12(1):21-7.
• Madabushi S, Yao H, Marsh M, Kristensen DM, Philippi A, Sowa ME, Lichtarge O. Structural clusters of evolutionary trace residues are statistically significant and common in proteins. J Mol Biol. 2002 Feb 8;316(1):139-54.
• Lichtarge O, Sowa ME, Philippi A. Evolutionary traces of functional surfaces along G protein signaling pathway.Methods Enzymol. 2002;344:536-56.
• Sowa ME, He W, Slep KC, Kercher MA, Lichtarge O, Wensel TG. Prediction and confirmation of a site critical for effector regulation of RGS domain activity.Nat Struct Biol. 2001 Mar;8(3):234-7.
• Sowa ME, He W, Wensel TG, Lichtarge O. A regulator of G protein signaling interaction surface linked to effector specificity. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1483-8.
• Melia TJ, Sowa ME, Schutze L, Wensel TG. Formation of helical protein assemblies of IgG and transducin on varied lipid tubules. J Struct Biol. 1999 Dec 1;128(1):119-30.

Last edited on: May 31, 2005