SCBMB: Ph.D. Program in Structural and Computational Biology and Molecular Biophysics at Baylor College of Medicine, Houston, TX

Juan Chang, Ph.D.

Baylor College of Medicine

Department: Biochemistry & Molecular Biology
Address: One Baylor Plaza, BCM125
Houston, TX 77030
Phone: 713-798-6989
Fax:
Email: juan.chang@bcm.tmc.edu
Web: ncmi.bcm.tmc.edu

Education

B.S. Biochemistry, University of Texas at Austin (1999)
B.S. Computer Science, University of Texas at Austin (2000)
Ph.D. Structural & Computational Biology, Baylor College of Medicine (2007)

Honors

Microscopy Society of America (MSA) and American Association of Anatomists (AAA) Student Travel Award (2005), Honolulu HI, July 31- Aug4
4th International Congress on Electron Tomography (4ICET) Student Travel Award (2006), San Diego CA, Nov 5-8
Sealy Center 12th Structural Biology Symposium Student Poster Award (2007) Galveston TX, May 18-19

Research Topic

Structural biology

Dissertation

Synergistic Approaches for Virus Structure Determination

Research Description

Low-dose cryo electron microscopy (cryoEM) and tomography (cryoET) of biological specimens, including viruses, prokaryotic and eukaryotic cells, and protein complexes.

Selected Publications

Abstracts
Chang JT, Marsh M, Rixon F, Chiu W. (2005) Mr T: Automated Electron Cryotomography for JEOL 2010F TEM Microscopy and Microanalysis 11 (Suppl 2): 308-309 [link]
Marsh M, Chang J, Chen J, Lopez J, Chiu W. (2005) Three-Dimensional Architecture of Platelets in its Native State by Electron Cryotomography Blood (ASH Annual Meeting Abstracts) 106(11): 1658 [link]
[Also in 45th Meeting of the American Society for Cell Biology]
Marsh MP, Chang J, Chen J, Lopez J, Chiu w. (2007) Electron Cryo-tomography of Human Platelets Captures Exocytosis Pathway of Diverse Secretory Granules. Biophysical J Suppl: 389-Pos.
Schmid MF, Khant H, Chang J, Marsh M, Cruciano A, Chiu W. (2007) Aligning and averaging subvolumes extracted from an electron cryo-tomogram. Biophysical J Suppl: 2423-Pos.
Schmid MF, Marsh M, Cruciano A, Chang J, Khant H, Chiu W. (2006) Aligning and averaging single particles from a tomogram. American Chemical Society 62nd Southwest Regional Meeting
Articles
Jiang W, Chang J, Jakana J, Weigele P, King J, Chiu W. (2006) Structure of Epsilon 15 Bacteriophage Reveals Genome Organization and DNA Packaging/Injection Apparatus. Nature 439(7076): 612-616 [link]
Chang J, Weigele P, King J, Chiu W, Jiang W. (2006) Cryo-EM Asymmetric Reconstruction of Bacteriophage P22 Reveals Organization of its DNA Packaging and Infecting Machinery. Structure 14(6): 1073-1082 [link]
Chang JT, Schmid MF, Rixon FJ, Chiu W. (2007) Electron Cryo-Tomography Reveals the Portal in the Herpesvirus Capsid. Journal of Virology 81(4): 2065-2068 [Pubmed]
Pope WH, Weigele PR, Chang J, Pedulla ML, Ford ME, Houtz JM, Jiang W, Chiu W, Hatfull GF, Hendrix RW, King JA. (2007) Genome Sequence, Structural Proteins, and Capsid Organization of the Cyanophage Syn5: A "Horned" Bacteriophage of Marine Synechococcus. Journal of Molecular Biology 368(4): 966-981 [Pubmed]
Marsh MP, Chang JT, Booth CR, Liang N, Schmid MF, Chiu W. (2007) Modular Software Platform for Low-Dose Elecron Microscopy and Tomography Journal of Microscopy 228(3): 384-389. [link]
Chiu W, Chen D, Jakana J, Chang J, Jiang W, Ludtke SJ, Baker ML. (2006) Visualization of Biological Nano-Machines at Subnanometer Resolutions JEOL News 41(1): 12-17. [website]

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Last edited on: October 09, 2007