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Lynn Zechiedrich
Baylor College of MedicineDepartment: Molecular Virology & Microbiology and Biochemistry & Molecular BiologyAddress: Associate Professor, Department of Molecular Virology & Microbiology One Baylor Plaza MS:BCM-280 Houston, TX 77030 USA Phone: 713-798-5126 Fax: 713-798-7375 Email: elz@bcm.edu Web: www.bcm.tmc.edu/labs/zechiedrich |
Education
B.S. Zoology, University of Arkansas (1985)
Ph.D. Biochemistry, Vanderbilt University School of Medicine (1990)
Biochemistry, University of California (1997)
Honors
Burroughs Wellcome Fund New Investigator Award in the Toxicological Sciences, 1998-2002
Curtis Hankamer Research Award (Baylor College of Medicine), 1998-1999
Leukemia Society of America Special (Senior level) Postdoctoral Fellowship, 1994-1997
National Institutes of Environmental Health Sciences Center Pilot Study Grant (UCB), 1994
National Institutes of Health Postdoctoral Fellowship, 1991-1994
Fellowship from Juan March Institute, Madrid, Spain, to attend International workshop, 1997
Outstanding (First Place) Graduate Student Presentation, Student Research Day, Vanderbilt Univ., 1989
First Place, Graduate Student Oral Presentation, The Eastern Student Research Forum, Univ. of Miami School of Medicine, 1989
Outstanding Freshman Academic Scholarship, 1981; Music Scholarship 1981-1985
Research Topic
DNA topoisomererases and antimicrobial resistance
Research Description
Genetic, biochemical, structural and functional analyses of topoisomerases, DNA topology and multidrug efflux pumps.
Selected Publications
- R.W. Deibler, S. Rahmati, and E.L. Zechiedrich. (2001) Topoisomerase IV, alone, unknots DNA in E. coli. Genes & Dev. 15, 748-761.
- S. Rahmati, S. Yang, A.L. Davidson, and E.L. Zechiedrich. (2002) Control of the AcrAB multidrug efflux pump by quorum sensing regulator SdiA. Mol. Microbiol. 43, 677-685.
- S.Yang, S. Clayton Rahmati, and E.L. Zechiedrich. (2003) Relative contributions of AcrAB, MdfA and QdrA to quinolone resistance in Escherichia coli. J. Antimicrob. Chemother. 51, 545-556.
- G.R. Buck and E.L. Zechiedrich. (2004) DNA disentangling by type-2 topoisomerases. J. Mol. Biol. 340, 933-939.
- C.R. Lopez, S. Yang, R.W. Deibler, S.A.Ray, J. Pennington, R.J. DiGate, P.J. Hastings, S.M. Rosenberg, and E.L Zechiedrich. (2005) A role for topoisomerases III in a recombination pathway alternative to RuvABC. Mol. Microbiol.58, 80-101.
- G.L. Randall, B.M. Pettitt, G.R. Buck, and E.L. Zechiedrich. (2006) Electrostatics of DNA-DNA juxtapositions; Consequences for type II topoisomerase function. J. Phys.: Condens. Matter, in press.
- S. Yang and E.L. Zechiedrich (2006) Quorum sensing and multidrug efflux pumps in Escherichia coli. submitted
- J.F. Fogg, N. Kolmakova, H. Hansma, J.J. Perona and E.L. Zechiedrich. (2006) Writhe in small DNA circles. submitted
Lab Members
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Last edited on: March 07, 2006